Chances are, most of the 110,000 fans at Ann Arbor had no idea exactly where Appalachian State is located.

By the time they saw a blocked field goal in the final seconds Saturday, this much was certain: The little Mountaineers pulled off one of the greatest upsets in college football history.

Appalachian State 34, No. 5 Michigan 32.

The upset notwithstanding, Big Ten teams ran up a 7-3 record against nonconference opponents on opening day. Indiana blasted visiting Indiana State 55-7; Iowa beat Northern Illinois 16-3 at Chicago; Michigan State dominated Alabama-Birmingham 55-18 at East Lansing; Northwestern shut out invading Northeastern 27-0; Ohio State was a 38-6 home field win over Youngstown State; Penn State overwhelmed visiting Florida International 59-0; Purdue won 52-24 at Toledo; Wisconsin beat Washington State 42-21 at Madison; Missouri beat Illinois 40-34 at St. Louis; and Bowling Green won a 32-31 overtime squeaker at Minnesota.

At Michigan, the team from Boone, N.C., took the lead with 26 seconds left when Julian Rauch kicked a 24-yard field goal. Corey Lynch blocked a 37-yard try on the final play, and the Mountaineers sealed a jaw-dropping upset that might have no equal.

The two-time defending champions from former Division I-AA were ahead of the nation’s winningest program 28-14 late in the second quarter, then their storybook afternoon seemed to unravel late in the fourth quarter.

Mike Hart’s 54-yard run put the Wolverines ahead – for the first time since early in the second quarter – with 4:36 left. But the Wolverines were unable to follow up and the Mountaineers came back for the win.

At Bloomington, Indiana quarterback Kellen Lewis threw the two longest touchdown passes of his career and ran for another score as Indiana routed Indiana State in the Hooisers’ first game since the death of coach Terry Hoeppner.

Lewis was 12-of-21 for 285 yards and three touchdowns – all on his first four passes – in the most lopsided season-opening win for Indiana (1-0) since a 72-0 victory over Fort Knox on Sept. 16, 1944.

The Hawkeyes’ eighth all-time rusher, Albert Young, gave Iowa a 6-0 lead on a 7-yard run early in the second quarter after Andy Brodell returned a punt 56 yards.

At East Lansing, Jehuu Caulcrick ran for 93 yards and a career-high four touchdowns as Michigan State rolled past UAB to give Mark Dantonio a win in his debut as Spartan coach..

Michigan State (1-0) and Dantonio, a former Cincinnati head coach, wasted no time unveiling an offense that is more run-oriented and physical than the system used under former coach John L. Smith. The Spartans rolled up 593 yards of offense.

In Northwestern’s shutout of Northeastern, C.J. Bacher threw for one touchdown and rushed for another.

Bacher, a junior who missed six games last fall with a stress fracture in his left leg, was 23-of-28 for 243 yards and capped the Wildcats’ opening drive with a 5-yard touchdown run.

With its win over Youngstown State, No. 11 Ohio State took its first step toward forgetting the end of last season.

Ohio State welcomed the game as a way to put some distance between themselves and the painful memories of a humiliating 41-14 defeat to Florida in the BCS national championship game Jan. 8.

At Madison, new starting quarterback Tyler Donovan threw for three touchdowns and ran for another to help No. 7 Wisconsin shake off a mediocre defensive performance in its win over Washington State.